Note4Students
From UPSC perspective, the following things are important :
Prelims level: Ultra-Conserved Elements (UCEs) in DNA
Why in the News?
Researchers have discovered a reason why certain segments of the human and mouse genomes (Tra2b gene) have remained unchanged for 80 million years. These segments, known as ultra-conserved elements (UCEs), play a vital role in regulating protein production
What are Ultra-Conserved Elements (UCEs) in DNA?
- Ultra-Conserved Elements (UCEs) are long, highly conserved DNA sequences (200+ base pairs) that have remained unchanged for millions of years across multiple species, including humans, mice, rats, chickens, and even fish.
- Key Characteristics:
- Found in both coding (gene) and non-coding (regulatory) regions of the genome.
- Do not tolerate mutations, meaning they remain identical across species for tens of millions of years.
- Many UCEs do not code for proteins but play crucial roles in gene regulation and cellular function.
- Their importance:
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- Evolutionary Significance: Their extreme conservation suggests they are essential for survival, as any mutation would likely be harmful.
- Gene Regulation: UCEs may function as enhancers or silencers, controlling when and where genes are activated.
- Developmental Roles: They are often linked to brain development, fertility, and immune response.
- Disease Prevention: UCEs may protect against genetic disorders and cancers by stabilizing gene expression.
Why do Human and Mouse Genomes overlap?
- Humans and mice share a common mammalian ancestor that lived around 80 million years ago.
- Genomic Similarity:
- Around 85% of mouse genes have direct counterparts in humans.
- Nearly 500 UCEs are identical between humans and mice, despite millions of years of evolution.
- Many fundamental processes like cell division, metabolism, and brain function are similar between species, necessitating high conservation of crucial DNA regions.
- Medical Research:
- Because of these similarities, mice serve as a model organism for studying human genetics, diseases, and drug responses.
- UCEs help scientists understand gene function across species, leading to insights into evolution and biomedical advancements.
PYQ:[2013] Recombinant DNA technology (Genetic Engineering) allows genes to be transferred 1. across different species of plants 2. from animals to plants 3. from microorganisms to higher organisms Select the correct answer using the codes given below: (a) 1 only (b) 2 and 3 only (c) 1 and 3 only (d) 1, 2 and 3 |
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