Innovations in Biotechnology and Medical Sciences

The conservation argument for resurrecting dire wolf is not credible

Why in the news?

Colossal Biosciences is an American company that combines genetics and conservation in a unique way by bringing back species that have been extinct for thousands of years.

What is the primary goal of Colossal Biosciences’ de-extinction project?

Colossal Biosciences is a biotechnology company specializing in de-extinction projects, aiming to revive extinct species through advanced genetic engineering.

  • Woolly Mammoth De-Extinction: Colossal is working to resurrect the woolly mammoth by integrating mammoth genes into the Asian elephant genome using CRISPR technology. The goal is to create a cold-resistant elephant with traits characteristic of the woolly mammoth, such as a thick layer of fat and shaggy hair, to inhabit Arctic tundra regions and potentially combat climate change.
  • Dire Wolf Revival: In a groundbreaking achievement, Colossal announced the birth of three pups—Romulus, Remus, and Khaleesi—genetically engineered to resemble the extinct dire wolf. Using DNA from ancient dire wolf remains, scientists edited the genes of modern gray wolves, resulting in animals that exhibit traits such as larger size and distinctive fur color.

Why do critics question the credibility of reviving extinct species for conservation purposes?

  • Lack of Scientific Proof: The actual success of reviving extinct species like the woolly mammoth has not yet been proven through rigorous peer review or established results.
  • Limited Genetic Editing: The extent of genetic editing in revived species often involves only a small number of genes, leading to incomplete or flawed replicas of the original species. Eg: In the case of the dire wolf, only 20 genes were edited, resulting in what critics describe as just a “strange-looking gray wolf” rather than a true de-extinct species.
  • Ethical Concerns: There are ethical debates over the potential consequences of creating species that may not thrive in the modern environment or might cause unforeseen ecological imbalances. Eg: The introduction of revived species like the woolly mammoth could disrupt current ecosystems in ways that may not be beneficial.

How can bringing back the woolly mammoth help stop global warming?

  • Restoring Grasslands: The woolly mammoth can help restore Arctic grasslands by grazing on shrubs and plants, which would create open grasslands where permafrost can remain intact. Eg: By grazing, mammoths would prevent the growth of shrubs that trap heat, promoting the return of grasslands that are cooler and better at reflecting sunlight.
  • Slowing Permafrost Melt: Grasslands absorb less heat than shrub forests, helping to keep the permafrost cool. The return of woolly mammoths could help prevent the thawing of permafrost, which releases methane, a potent greenhouse gas. Eg: Mammoth grazing can keep the ground cooler and slow the thawing of permafrost, thus reducing the release of methane into the atmosphere.
  • Preventing Methane Emissions: As the permafrost melts, it releases large amounts of methane into the atmosphere. Woolly mammoths could help mitigate this by maintaining ecosystems that slow down the permafrost’s thaw. Eg: With mammoths grazing, the tundra could remain cooler and less prone to releasing methane.
  • Enhancing Carbon Sequestration: Grasslands are more effective at absorbing carbon than shrubbery or forested areas. By converting tundra back into grasslands, woolly mammoths could enhance carbon sequestration and help store more carbon in the soil. Eg: Woolly mammoths could help re-establish healthy grasslands, which would act as carbon sinks, absorbing more CO2 from the atmosphere.

What is India’s situation in advanced genetic engineering?

  • Advancements in Agricultural Biotechnology: India has developed a structured regulatory framework for genetically modified organisms (GMOs) under the Environment (Protection) Act, of 1986. Eg: Recently, India initiated trials of CRISPR/Cas9-modified rice varieties in test fields, reflecting a surge in scientific research and innovation in plant genome editing.
  • Pioneering Genomic Research and Precision Medicine: India’s Genome India Project aims to sequence at least 10,000 Indian genomes to develop predictive diagnostic indicators for various diseases. Eg: Institutions like the Institute of Genomics and Integrative Biology (IGIB) have been instrumental in understanding genetic epidemiology, including the development of the FELUDA COVID-19 test based on CRISPR technology.

Way forward: 

  • Strengthen Ethical and Regulatory Frameworks: India should establish robust regulations and ethical guidelines for genetic engineering, particularly for gene-editing technologies like CRISPR, to ensure safety and sustainability in areas such as agriculture and medicine.
  • Promote Collaborative Research and Innovation: Encouraging partnerships between academic institutions, the private sector, and the government will help accelerate research and application of advanced genetic technologies, positioning India as a global leader in biotechnology innovation.

Mains PYQ: 

[UPSC 2024] What strategies have been developed to prevent such a catastrophe [mass extinction of life]?

Linkage: The article says we should focus more on saving the species that are alive today, rather than trying to bring back extinct ones. The debate about de-extinction raises the question of whether it’s better to spend resources on protecting current species instead.

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