Introduction

To combat the menace of growing antibiotic resistance, scientists at CSIR-Indian Institute of Integrative Medicine (IIIM), Jammu, have made a groundbreaking discovery.
They found that phytocannabinoids, compounds found in the cannabis plant, possess previously untapped antibiotic properties.

Understanding India’s AMR Challenge

Escalating AMR Threat: AMR occurs when bacteria, viruses, fungi, and parasites no longer respond to antibiotics, leading to increased disease risk and treatment complications.
Alarming Statistics: In 2019, India reported 2.97 lakh deaths attributed to AMR and 10.42 lakh linked to AMR-related factors.
Contributing Factors: Overuse of antibiotics, misuse in animal husbandry, and inadequate waste disposal practices are exacerbating AMR, potentially making India the “AMR capital of the world.”

Phytocannabinoid Research: IIIM researchers explored the antibiotic properties of tetrahydrocannabidiol (THCBD), a semisynthetic phytocannabinoid derived from cannabis.
Fighting MRSA: THCBD exhibited remarkable efficacy against Methicillin-resistant Staphylococcus aureus (MRSA), a highly resistant strain of bacteria responsible for numerous deaths worldwide.
Synergy with Existing Antibiotics: THCBD complemented or showed indifference to common antibiotics like mupirocin, penicillin G, and ciprofloxacin, suggesting potential combinatory treatments.

Legal Constraints: Cannabis research faces legal constraints due to its intoxicating properties, making collaboration with other institutes challenging.
Policy Advocacy: The research project aims to advocate for a unified national policy for cannabis research, highlighting its antibacterial potential and transforming it into a valuable resource.

Collaborative Efforts: IIIM researchers seek collaborations to expedite their progress in developing THCBD as a potential drug.
Addressing Solubility Challenge: Ensuring THCBD’s solubility is a critical step. The molecule leans slightly towards lipophilicity, requiring optimization for proper absorption in biological systems.
Healthcare Impact: This research not only promises significant contributions to the healthcare system but also offers economic benefits by establishing related industries and creating sustainable job opportunities.