Note4Students
From UPSC perspective, the following things are important :
Prelims level: Geroscience, DNA Methylation
Mains level: NA
Why in the news?
- Dr. Daniel Belsky from Columbia University introduced the concept of “Geroscience” and develops a blood test, termed “gerozyme,” to measure aging pace by studying DNA methylation.
- Various research groups explore drugs like Metformin and Rapamycin to target aging and enhance immunity in the elderly.
What is Geroscience?
- Geroscience refers to the interdisciplinary field focused on understanding the biological mechanisms of ageing and age-related diseases.
- It involves studying various factors, including DNA methylation, enzyme activity (such as the gerozyme), socio-economic influences, and lifestyle interventions like nutrition, exercise, and music therapy.
- It aims to develop strategies, such as drug interventions targeting specific ageing-related processes, to promote healthy ageing and combat age-related conditions like dementia.
What is DNA Methylation?
|
Drug Interventions in Geroscience
- Metformin and TORC1 inhibitors show promise in targeting aging and improving immune response in seniors.
- Research proposes rapamycin’s potential in extending longevity and combating age-related diseases.
Impact of Socio-Economic Factors in Ageing
- Dr. Belsky’s research reveals the influence of socioeconomic status on DNA methylation levels, highlighting the role of disadvantage in ageing.
- Columbia Aging Centre emphasizes the role of a balanced diet in supporting brain health and reducing inflammation.
- Healthline.com advocates for proteins, healthy fats, and antioxidant-rich foods to promote healthy ageing, crucial for India’s ageing population.
PYQ:[2011] At present, scientists can determine the arrangement or relative positions of genes or DNA sequences on a chromosome. How does this knowledge benefit us?
Which of the statements given above is/are correct? (a) 1 and 2 only (b) 2 only (c) 1 and 3 only (d) 1, 2 and 3 |
Get an IAS/IPS ranker as your 1: 1 personal mentor for UPSC 2024