Note4Students
From UPSC perspective, the following things are important :
Prelims level: Plasma Therapy; Plasmapheresis, Components of Human Blood;
Mains level: NA
Why in the news?
- A significant health concern in Tamil Nadu is found through ingestion of Rat poison containing Yellow Phosphorus, leading to liver toxicity.
- Since December 2017, the team at CMC Vellore introduced Plasma Exchange, (a cost-effective treatment) for acute liver failure caused by rat poison ingestion.
What is Plasma Therapy (Plasmapheresis)?
- Plasma exchange, also known as plasmapheresis, is a medical procedure used to treat various conditions by removing and replacing plasma from the blood.
- During Plasma Exchange, the patient’s blood is circulated through a machine that separates plasma from other blood components, such as red and white blood cells and platelets.
Working procedure:
- The plasma, which may contain harmful substances or antibodies, is discarded.
- The remaining blood components are mixed with replacement plasma or a plasma substitute and returned to the patient’s bloodstream.
Usage of Plasmapheresis:
- In Autoimmune diseases: Conditions such as Guillain-Barre syndrome, myasthenia gravis, systemic lupus erythematosus, and certain forms of vasculitis.
- In Neurological disorders: Conditions such as multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, and certain types of encephalitis.
- In Toxicological emergencies: Poisoning or overdose with substances such as drugs, chemicals, or toxins that can be removed from the bloodstream through plasma exchange.
Benefits observed in TN’s Case
- The treatment significantly improved survival rates, with 63.9% of patients treated in 2022-2023 successfully discharged.
- Retrospective studies at CMC Vellore demonstrated promising outcomes, with survival rates of 75% among children and 80.2% among adults treated with plasma exchange.
What is Plasma in Human Blood?
Composition:
Functions:
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PYQ:[2011] A married couple adopted a male child. A few years later, twin boys were born to them. The blood group of the couple is AB positive and 0 negative. The blood group of the three sons is A positive, B positive, and O positive. The blood group of the adopted son is- (a) O positive (b) A positive (c) B positive (d) Cannot be determined based on the given data |
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