Innovations in Biotechnology and Medical Sciences

Plasma Therapy to Treat Rodenticide Poisoning

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Plasma Therapy; Plasmapheresis, Components of Human Blood;

Mains level: NA

Why in the news?

  • A significant health concern in Tamil Nadu is found through ingestion of Rat poison containing Yellow Phosphorus, leading to liver toxicity.
    • Since December 2017, the team at CMC Vellore introduced Plasma Exchange, (a cost-effective treatment) for acute liver failure caused by rat poison ingestion.

What is Plasma Therapy (Plasmapheresis)?

  • Plasma exchange, also known as plasmapheresis, is a medical procedure used to treat various conditions by removing and replacing plasma from the blood.
  • During Plasma Exchange, the patient’s blood is circulated through a machine that separates plasma from other blood components, such as red and white blood cells and platelets.

Working procedure:

  • The plasma, which may contain harmful substances or antibodies, is discarded.
  • The remaining blood components are mixed with replacement plasma or a plasma substitute and returned to the patient’s bloodstream.

Usage of Plasmapheresis:

  • In Autoimmune diseases: Conditions such as Guillain-Barre syndrome, myasthenia gravis, systemic lupus erythematosus, and certain forms of vasculitis.
  • In Neurological disorders: Conditions such as multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, and certain types of encephalitis.
  • In Toxicological emergencies: Poisoning or overdose with substances such as drugs, chemicals, or toxins that can be removed from the bloodstream through plasma exchange.

Benefits observed in TN’s Case

  • The treatment significantly improved survival rates, with 63.9% of patients treated in 2022-2023 successfully discharged.
  • Retrospective studies at CMC Vellore demonstrated promising outcomes, with survival rates of 75% among children and 80.2% among adults treated with plasma exchange.

What is Plasma in Human Blood?

  • Human blood plasma is the liquid component of blood, constituting about 55% of its total volume.
  • It is a pale yellowish fluid that carries various substances throughout the body, including nutrients, hormones, electrolytes, antibodies, and waste products.
  • Plasma plays a crucial role in maintaining homeostasis and transporting essential components to tissues and organs.

Composition:

  • Water: Approximately 90% of plasma consists of water, making it the primary solvent for carrying dissolved substances.
  • Proteins: Plasma contains a variety of proteins, including albumin, globulins, and fibrinogen. These proteins perform functions such as maintaining osmotic pressure, transporting lipids and hormones, and aiding in blood clotting.
  • Electrolytes: Plasma contains ions such as sodium, potassium, chloride, calcium, and bicarbonate, which help regulate fluid balance, pH, and nerve function.
  • Nutrients: Glucose, amino acids, lipids, and vitamins are transported in plasma and provide energy and building blocks for cells.
  • Waste Products: Metabolic waste products, such as urea, creatinine, and bilirubin, are transported in plasma to be eliminated from the body.
  • Hormones: Hormones produced by endocrine glands are carried in plasma to target tissues, where they regulate various physiological processes.
  • Gases: Oxygen and carbon dioxide are transported in plasma, primarily bound to hemoglobin in red blood cells.

Functions:

  • Plasma carries nutrients, gases, hormones, and waste products to and from cells throughout the body.
  • Plasma helps regulate fluid balance, electrolyte concentrations, pH, and temperature.
  • Antibodies and immune cells in plasma help defend against pathogens and foreign substances, contributing to the body’s immune response.
  • Plasma proteins such as fibrinogen play a crucial role in blood clotting, helping to stop bleeding and repair damaged blood vessels.
  • Plasma buffers changes in pH by absorbing or releasing hydrogen ions, helping maintain the body’s acid-base balance.

 

PYQ:

[2011] A married couple adopted a male child. A few years later, twin boys were born to them. The blood group of the couple is AB positive and 0 negative. The blood group of the three sons is A positive, B positive, and O positive. The blood group of the adopted son is-

(a) O positive

(b) A positive

(c) B positive

(d) Cannot be determined based on the given data

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