Note4Students
From UPSC perspective, the following things are important :
Prelims level: Mitochondrial Replacement Therapy (MRT)
Mains level: Various ARTs
Central Idea
- The birth of a baby using three persons’ DNA using Mitochondrial Replacement Therapy (MRT) in the UK has generated significant attention and discussion.
- The baby has three parents, with the mitochondria coming from a donor in addition to the genetic material from the biological parents.
- This pioneering technology was employed to prevent the baby from inheriting the mother’s mitochondrial disease.
What is Mitochondria?
| Description | |
| Structure | Membrane-bound organelles with outer and inner membranes |
| Energy Production | Generate ATP through cellular respiration and oxidative phosphorylation |
| ATP Production | Breakdown of carbohydrates, fats, and proteins in the inner membrane |
| DNA and Replication | Possess their own circular DNA (mtDNA) and can replicate independently |
| Other Functions | Involved in calcium signalling, apoptosis, and synthesis of molecules |
| Inheritance | Maternally inherited during fertilization |
| Evolutionary Origin | Arise from a symbiotic relationship with bacteria-like organisms |
| Disorders | Mutations or dysfunction can cause mitochondrial diseases |
- Certain defects in mitochondria can lead to mitochondrial diseases, impacting the function of energy-hungry tissues in various organs.
- Mitochondrial diseases have no cure but can be treated, and their incidence is estimated to be one in 5,000 people.
- In this case, the mother had a mitochondrial disease that she wanted to avoid passing on to her baby, but she did not want to use a donor egg.
What is Mitochondrial Replacement Therapy (MRT)?
- MRT is a medical technique used to prevent the transmission of certain mitochondrial diseases from a mother to her child.
- It involves replacing faulty mitochondria in an egg or embryo with healthy mitochondria from a donor.
- The procedure is typically performed using in vitro fertilization (IVF) techniques.
- The nucleus, containing the majority of the genetic material, is transferred from the intended parents’ egg or embryo to a donor egg or embryo with healthy mitochondria.
- The resulting embryo, with nuclear DNA from the intended parents and healthy mitochondria from the donor, is then implanted into the mother’s uterus for gestation.
How does it work?
- The father’s sperm fertilizes the eggs from the biological mother and a female donor with healthy mitochondria.
- The genetic material from the donor’s egg is replaced with that of the biological parents, resulting in an egg with the parents’ DNA and the donor’s mitochondria.
- This modified egg is then implanted into the mother’s uterus and carried to full term, resulting in a baby free from the mother’s mitochondrial disease.
Uses of MRT
- Prevention of Mitochondrial Diseases: MRT helps prevent the transmission of certain mitochondrial diseases from mothers to their children.
- Family Planning: It enables individuals or couples with mitochondrial DNA mutations to have genetically related children without the risk of disease inheritance.
- Improved Health: MRT can significantly improve the overall health and well-being of individuals by avoiding debilitating mitochondrial diseases.
- Ethical Considerations: It provides an alternative to traditional donor egg options, allowing intended parents to have a child with their own genetic material while avoiding disease transmission.
- Scientific Advancements: MRT contributes to scientific research and advancements in assisted reproductive technologies, expanding our understanding of mitochondrial biology and potential treatment options for mitochondrial disorders.
Recent advancements in UK
- The baby primarily carries DNA from its biological parents and a small percentage from the donor whose mitochondria was used during fertilization.
Scientific process
- Mitochondrial diseases are inherited from the mother, prompting research to find ways to protect infants from inheriting these diseases.
- The Newcastle Fertility Clinic developed an advanced in vitro fertilization technique known as Mitochondrial Donation Treatment (MDT).
Legal Facilitation of MDT
- The UK government amended the law in 2015 to allow for mitochondrial replacement therapy (MRT) or MDT.
- The Newcastle Fertility Centre became the first center to obtain a license to perform the procedure, and the first cases were approved in 2018.
Issues with MRT
- Transfer of Defective Mitochondria: There is a minimal risk of transferring small amounts of defective mitochondria along with healthy ones during the procedure.
- Long-Term Safety: The long-term safety of MRT is still being studied, and ongoing monitoring is necessary to assess any potential risks or effects.
- Ethical and Social Concerns: MRT raises ethical and social considerations related to the creation and destruction of embryos, use of donor gametes, and altering the germline.
- Limited Availability: MRT is a highly regulated procedure, and its availability may be limited to specific countries or cases approved by regulatory bodies.
- Emotional and Psychological Impact: Undergoing MRT involves emotional implications and decision-making, which can have an impact on individuals and couples involved.
Get an IAS/IPS ranker as your 1: 1 personal mentor for UPSC 2024
