Innovations in Biotechnology and Medical Sciences

Unveiling the Link between Fairness Creams and Nephrotic Syndrome

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Mercury Poisoning, Membranous Nephropathy, Minamata Convention.

Mains level: NA

Why in the news?

  • Researchers from Kerala reported 15 cases of Membranous Nephropathy (MN) linked to the regular application of fairness creams.
  • These creams contained high levels of mercury, sometimes exceeding the safe limit by 10,000 times.

Mercury Contamination in Hair Cream

  • Blood and urine screenings of affected individuals unveiled alarmingly high levels of mercury, a well-known toxic element.
  • The fairness creams contained mercury levels up to 10,000 times above the permissible limit of 1 ppm under Minamata Convention (2013).
  • Most cases were PLA2R (phospholipase A2 receptor) negative, indicating a different cause.
  • Cases of MN linked to Neural epidermal growth factor-like protein 1 (NELL-1) have been identified.
  • NELL-1 has been associated with MN caused by traditional medicines containing high mercury levels.

Understanding Membranous Nephropathy

  • Membranous Nephropathy (MN) is a nephrotic syndrome, characterized by excessive protein leakage into urine, eventually leading to kidney failure. Symptoms such as fatigue, edema, and proteinuria were found to have a history of regular fairness cream usage.

Impact of Mercury:

  • Mercury in fairness creams inhibits melanin formation, resulting in lighter skin. Consumers perceive higher mercury levels as more effective for skin whitening.
  • Mercury, a potent heavy metal found in these creams, penetrates the body through various channels, including sweat glands and hair follicles, causing systemic toxicity.
  • Chronic exposure to mercury can result in kidney damage, neurological disorders, and a myriad of other health complications.

Back2Basics: Minamata Convention on Mercury

  • The Minamata Convention on Mercury is devised to safeguard human health and the environment from the detrimental impacts of mercury and its derivatives.
  • Its name derives from the Japanese bay where, during the mid-20th century, industrial wastewater tainted with mercury inflicted severe health damage upon thousands of individuals, leading to what is now recognized as “Minamata disease.”
  • Signed in 2013 and enforced in 2017, it operates as a United Nations treaty under the purview of the United Nations Environment Programme (UNEP).
  • Countries ratifying the Convention are legally obliged under international law to implement these regulations.
  • 128 countries are signatories, with 119 of them having ratified it; India became a party by ratifying it in 2018.

Activities covered by the Convention:

  • The Convention encompasses all phases of the mercury life cycle, aiming to regulate and diminish mercury usage across various products, processes, and industries.
  • This encompasses regulations about:
    • Mercury mining involves bans on new mines and the gradual phase-out of existing ones.
    • Gradual reduction and elimination of mercury utilization in numerous products and procedures.
    • Control measures address emissions into the atmosphere and release into soil and water bodies.
    • Oversight of the informal artisanal and small-scale gold mining sector.
    • Management of interim mercury storage and its disposal once classified as waste, as well as remediation of mercury-contaminated sites and associated health issues.

 

PYQ:

[2010] Indiscriminate disposal of used fluorescent electric lamps causes mercury pollution in the environment. Why is mercury used in the manufacture of these lamps?

(a) A mercury coating on the inside of the lamp makes the light bright white

(b) When the lamp is switched on, the mercury in the lamp causes the emission of ultra-violet radiations

(c) When the lamp is switched on, it is the mercury which converts the ultra-violet energy into visible light

(d) None of the statement given above is correct about the use of mercury in the manufacture of fluorescent lamps

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