💥UPSC 2027,2028 Mentorship (April Batch) + Access XFactor Notes & Microthemes PDF

Type: Prelims Only

  • Innovations in Biotechnology and Medical Sciences

    [pib] CAR T-Cell Therapy

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: CAR-T Cell Therapy

    Why in the News?

    The Department of Biotechnology (DBT) has been a key supporter of research projects focusing on CAR T-cell therapies for cancers.

    About CAR T-Cell Therapy:

    What is it?
    • Acronym  for Chimeric Antigen Receptor TCell Therapy;
    • Innovative  immunotherapy in which T-cells (a type of white blood cell) are genetically modified to express a receptor (CAR) that targets specific proteins on cancer cells.
    • T-cells are part of the immune system and help identify and eliminate infected or cancerous cells.
    Objective of the Therapy
    • To treat blood cancers, especially B Acute Lymphoblastic Leukemia (B-ALL) and Non-Hodgkin Lymphoma (B-NHL).
    • Aimed at patients whose disease relapsed or was resistant to conventional treatments (chemotherapy, radiation).
    • Specifically targets CD19, a protein found on the surface of B-cells, which includes cancerous B-cells.
    Implementation and Structural Mandate
    • Developed jointly by Indian Institute of Technology (IIT-Bombay) and Tata Memorial Center (TMC), Mumbai since 2015.
    • Approved by DCGI (Drug Controller General of India) in March 2021 for Phase 1 trials in children and adults with relapsed B-ALL and B-NHL.
    • Supported by academic grants from Department of Biotechnology and government agencies.
    • Trials were conducted at Tata Memorial Center (TMC), and other hospitals.
    Future Scope for Phase II
    • Phase 1 Trials: Conducted from 2021 to 2023 on children and adolescents with B-ALL and adults with B-NHL, with promising results matching international standards in terms of efficacy and safety.
    • Phase 2 Trials: Have been approved and are currently ongoing. These trials will expand on the efficacy and long-term safety of the therapy, including larger cohorts of patients.

    Future Scope: Holds the potential for expanding to other cancers, such as Multiple Myeloma, Glioblastoma, and Hepatocellular Carcinomas, based on continued research and results from Phase II trials.

     

    PYQ:

    [2022] Which one of the following statements best describes the role of B cells and T cells in the human body?

    (a) They protect the environmental allergens body.
    (b) They alleviate the body’s pain and inflammation.
    (c) They act as immuno-suppressants in the body.
    (d) They protect the body from diseases caused by pathogens.

  • Tuberculosis Elimination Strategy

    [pib] National Tuberculosis Elimination Programme (NTEP)

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: National TB Elimination Programme (NTEP)

    Why in the News?

    The Union Ministry of Health has re-strategized the National Tuberculosis Elimination Programme (NTEP) under the 100-Day TB Elimination Campaign to reduce TB cases and mortality through targeted interventions and a multi-pronged approach.

    Menace of TB in India:

    • According to the World Health Organization (WHO), India accounted for 26% of global TB cases and deaths in 2023.
    • The Indian Council of Medical Research (ICMR) conducted a National TB Prevalence Survey in 20 states, reporting 312 TB cases per lakh population.
      • The TB incidence rate decreased by 17.7%, from 237 per 100,000 in 2015 to 195 per 100,000 in 2023.
      • Similarly, TB-related deaths have declined by 21.4%, from 28 per lakh population in 2015 to 22 per lakh population in 2023.

    About the National TB Elimination Programme (NTEP):

    Details
    About
    • Former Name: Revised National Tuberculosis Control Programme (RNTCP)
    • Objective: To eliminate tuberculosis (TB) as a public health issue in India by 2025, as per PM Modi’s 2018 target.
    • Focus Areas: Early detection, complete treatment, prevention, and strengthening TB care and control services.

    Key Components of NTEP:

    • Universal Drug Susceptibility Testing (UDST): Early detection of drug-resistant TB.
    • Free Diagnosis and Treatment: Provided for all TB patients across India.
    • Nikshay: A case-based web-enabled TB information system for monitoring and case management.
    • Private Sector Engagement: Involving private healthcare providers for standardized care.
    Objectives under the National Strategic Plan 100-Day TB Elimination Campaign is an intensified effort launched to fast-track the detection and treatment of tuberculosis (TB) cases across the country.

    • Eliminate TB as a public health problem by 2025.
    • Achieve Universal Access to quality TB care.
    • Prevent the emergence of drug-resistant TB through early diagnosis and appropriate treatment.
    • Reduce the burden of TB through preventive interventions and awareness campaigns.
    • Ensure better case management through Nikshay, a case-based monitoring system.
    • 6. Engage with the private sector to ensure standardized and quality TB care.
    Steps taken by Govt
    • Universal Drug Susceptibility Testing (UDST): Early detection of drug-resistant TB.
    • Free Diagnosis and Treatment: Provided for all TB patients.
    • Nikshay System: Web-enabled case-based monitoring and management system for TB patients.
    • Private Sector Engagement: Ensuring standardized TB care by involving private healthcare providers.
    • National TB Prevalence Survey: Conducted to assess the TB burden in 20 states.
    • Enhanced Diagnostic Facilities: Including genetic and molecular tests for early detection.
    • Targeted Interventions for Vulnerable Populations: Focus on high-risk groups, including children and marginalized populations.
  • Indian Navy Updates

    Commissioning of INS TUSHIL

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: INS TUSHIL

    Commissioning of INS TUSHIL

    Why in the News?

    INS Tushil, a multi-role stealth guided missile frigate, is set to be commissioned by the Indian Navy at Kaliningrad, Russia.

    About INS Tushil:

    Details
    • INS Tushil is a multi-role stealth guided missile frigate, part of the Krivak III class (Project 1135.6).
    • It is the seventh in the series of Krivak III frigates, following the Talwar-class ships (three built at Baltiysky Shipyard in St. Petersburg) and the Teg-class ships (three built at Yantar Shipyard in Kaliningrad).

    Development of INS Tushil:

    • Built at Yantar Shipyard in Kaliningrad, Russia.
    • Contract signed in Oct 2016 between Indian Navy, JSC Rosoboronexport, and Government of India.
    • Indian team of specialists from the Warship Overseeing Team monitored the construction.
    • Extensive trials, including Factory Sea Trials, State Committee Trials, and Delivery Acceptance Trials, were conducted in 2024.
    Special Features
    • Speed of over 30 knots
    • Stealth design with advanced radar-absorbing features.
    • Equipped with guided missiles, advanced weapon systems, and radars.
    • Enhanced combat capabilities with a focus on anti-surface and anti-air warfare.
    • Helicopter deck for operations.
    Significance
    • Boosts India’s naval capabilities in the Indian Ocean Region (IOR).
    • Part of an ongoing effort to modernize the fleet with advanced technologies.
    • Strengthens India-Russia defence ties.
    • Will be key in maritime security and regional defense, especially in contested waters.
  • Festivals, Dances, Theatre, Literature, Art in News

    Nagaland’s Hornbill Festival

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Hornbill Festival

    Why in the News?

    This year’s edition of the Hornbill Festival has sparked a significant public debate regarding the relaxation of Nagaland’s liquor prohibition law, a subject that has been contentious for over three decades.

    What is Hornbill Festival?

    • The Hornbill Festival is a celebration held every year from 1 – 10 December, in Kohima, Nagaland.
    • The festival was first held in the year 2000.
    • It is named after Indian hornbill (Buceros bicornis), the large and colourful forest bird which is displayed in the folklore of most of the state’s tribes.
    • Festival highlights include the traditional Naga Morungs exhibition and the sale of arts and crafts, food stalls, herbal medicine stalls, flower shows and sales, cultural medley – songs and dances, fashion shows etc.
    • It is a platform for showcasing the major cultural festivals of 14 recognised Naga tribes, each with its unique traditions and practices.
    • About Great Indian Hornbill:
      • IUCN Status: Vulnerable (upgraded from Near Threatened in 2018), CITES: Appendix I
      • Known as great pied hornbill, it is one of the largest hornbill species.
      • Can live up to 50 years in captivity.
      • Primarily fruit-eating, but also preys on small mammals, reptiles, and birds.
      • Revered in many tribal cultures and rituals due to its size and colour.
      • Found mainly in India, especially in the Western Ghats and Nilgiris.
      • Nilgiris North Eastern Range supports some of the highest densities of nesting birds.
      • Known as ‘forest engineers’ or ‘farmers of the forest’, they play a key role in seed dispersal of tropical trees, indicating the health and balance of their forest ecosystems.

    What is the Nagaland Liquor Total Prohibition (NLTP) Act 1989?

    • The NLTP Act is a law enacted by the Government of Nagaland that prohibits the production, sale, and consumption of alcohol in the state.
    • The Act is one of the most stringent liquor prohibition laws in India, and its core features are as follows:
    • Key Features of NLTP Act 1989:
      • Complete Ban on Alcohol: The NLTP Act bans the production, sale, and consumption of all forms of alcoholic beverages, including beer, wine, and spirits. This includes both local (like rice beer) and commercial alcohol.
      • Exceptions: There are some exceptions under the law, such as alcohol being allowed for medical or scientific purposes and in certain regulated settings, like special licenses for non-local tourists during specific events (e.g., the Hornbill Festival).
      • Support from Religious Groups: The Act has received strong support from Christian church bodies, which constitute a majority in the state, as they view alcohol consumption as morally unacceptable and harmful to community life.

    Role of Alcohol in the Hornbill Festival:

    • The Hornbill Festival is often seen as an exception to the state’s liquor prohibition.
    • Thutse (local rice beer) is traditionally consumed during the festival, and according to academic Theyiesinuo Keditsu, the Hornbill Festival is the only time in the year when the state permits the open sale and consumption of alcohol, including Thutse.

     

    PYQ:

    [2016] In which of the following regions of India are you most likely to come across the ‘Great Indian Hornbill’ in its natural habitat?

    (a) Sand deserts of northwest India

    (b) Higher Himalayas of Jammu and Kashmir

    (c) Salt marshes of western Gujarat

    (d) Western Ghats

  • Higher Education – RUSA, NIRF, HEFA, etc.

    [pib] National Library Mission

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: National Library Mission

    Why in the News?

    The Union Minister for Culture and Tourism has provided information regarding the National Mission on Libraries (NML) Scheme in Rajya Sabha.

    About National Mission on Libraries (NML):

    Establishment Launched in 2012 by the Ministry of Culture to implement National Knowledge Commission (NKC, 2005) recommendations on library and information sciences development.
    Objectives To modernize public libraries, create a digital database, enhance library staff competence, and promote equitable library access, especially in backward areas.
    Structural Mandate Nodal Agency: Raja Rammohun Roy Library Foundation (RRRLF), Kolkata to oversee and coordinate efforts. (It is an autonomous body under the Ministry of Culture.)

    Key Components:

    1. National Virtual Library of India (NVLI): Digital resources, census of libraries, and reading habit studies.
    2. Model Libraries: 6 Ministry libraries, 35 state central libraries, 35 district libraries, and 629 district libraries with network connectivity.
    3. Library Survey: A survey of 5,000 libraries for infrastructure, resources, and usage data.
    4. Capacity Building: Training programs for improving skills and knowledge of library staff.

     

    PYQ:

    [2015] India’s Traditional Knowledge Digital Library (TKDL) which has a database containing formatted information on more than 2 million medicinal formulations is proving a powerful weapon in country’s fight against erroneous patents. Discuss the pro and cons of making the database available publicly available under open source licensing.

  • [pib] National Mission on Cultural Mapping  

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: National Mission on Cultural Mapping (NMCM)

    Why in the News?

    The Union Minister for Culture and Tourism has provided details of the National Mission on Cultural Mapping in the Rajya Sabha.

    About National Mission on Cultural Mapping (NMCM):

    Details
    • Launched by: Ministry of Culture, Government of India.
    • Implemented by: Indira Gandhi National Centre for the Arts (IGNCA).
    Aims and Objectives
    • Document India’s cultural heritage, including art forms, artists, crafts, and performing arts.
    • Mapping of 6.5 lakh villages across India; Initial stages will focus on Bihar.
    • IT-enabled platform to store and manage cultural data. Web portal and mobile app (Mera Gaon Meri Dharohar).
    Mera Gaon Meri Dharohar (MGMD):

    • Part of NMCM, by the Ministry of Culture and IGNCA.
    • Purpose: Documents India’s villages, focusing on culture, history, and traditions.
    • 7 Categories: Covers Arts & Crafts, Ecology, Scholastic Traditions, Epics, History, Architecture, and unique features.
    Features
    • Raise awareness about cultural heritage’s role in economic development and national unity.
    • Create National Register of Artists and Art Practices.

     

    PYQ:

    [2018] Safeguarding the Indian Art Heritage is the need of the moment. Discuss.

  • [pib] National Cooperative Policy

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: National Cooperative Policy

    Why in the News?

    • The Union Minister of Cooperation has provided crucial information regarding India’s National Cooperative Policy to the Lok Sabha.
      • The new National Cooperative Policy is almost ready and will be announced in 2-3 months.

    Update regarding the New National Cooperative Policy:

    Details
    National Level Committee Formation • A 48-member National Level Committee was formed under the chairmanship of Shri Suresh Prabhakar Prabhu.
    • The committee includes experts from the cooperative sector, representatives from National, State, District, and Primary level cooperative societies, and officers from Central Ministries/Departments.
    • The task of the committee was to formulate the New National Cooperation Policy for the development of the cooperative sector in India.
    17 meetings and 4 regional workshops were conducted across the country to finalize the draft report of the policy.
    Aims and Objectives Revitalize the cooperative sector and enhance its efficiency at national, state, district, and primary levels.
    Strengthen the cooperative movement in India by creating a structured policy that fosters growth and sustainability.
    • Establish financial viability and governance mechanisms for cooperatives.
    • Ensure cooperative federalism by allowing state cooperatives to function autonomously, avoiding undue centralization.
    Features of the Policy • The policy adopts an inclusive approach, including all levels of cooperatives from district to primary.
    • Close collaboration with State Governments to promote the cooperative sector and implement cooperative federalism.
    • The draft policy was developed after extensive consultations, ensuring broad public and expert participation.
    Provisions under the Policy Strengthening Cooperative Structure: Set up District Central Cooperative Banks (DCCBs) and district milk producers’ unions in all uncovered districts. NABARD will prepare an action plan for this.
    Expansion of Multipurpose PACS: New multipurpose PACS, primary dairy/fishery cooperative societies will be established in uncovered Panchayats/villages across India within the next five years.

     

    PYQ:

    [2011] In India, which of the following have the highest share in the disbursement of credit to agriculture and allied activities?

    (a) Commercial Banks

    (b) Cooperative Banks

    (c) Regional Rural Banks

    (d) Microfinance Institutions

  • Festivals, Dances, Theatre, Literature, Art in News

    [pib] Maha Kumbh Mela, 2025

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Kumbh Mela

    Why in the News?

    The 2025 Maha Kumbh Mela will take place in Prayagraj from January 13 to February 26.

    [pib] Maha Kumbh Mela, 2025

    About Kumbh Mela

    Details A major pilgrimage and festival in Hinduism, occurring four times in twelve years at different locations in India. It attracts millions of pilgrims for spiritual purification.

    Types of Kumbh Mela:

      1. Kumbh Mela: Regular festival, celebrated every 12 years at one of the four locations.
      2. Maha Kumbh Mela: The largest, celebrated once every 12 years at Prayagraj (confluence of Ganges, Yamuna, and Sarasvati).
      3. Ardh Kumbh Mela: Held every 6 years in Prayagraj (half of the full Kumbh Mela).
    • Purna Kumbh Mela: Held when a complete 12-year cycle is completed.

    Locations:  Kumbh Mela rotates between four cities:

      1. Haridwar (on the banks of the Ganges),
      2. Prayagraj (confluence of the Ganges, Yamuna, and the mythical Sarasvati river),
      3. Ujjain (on the banks of the Shipra River),
    • Nashik (on the banks of the Godavari River).

    Key Rituals:

    • Shahi Snan (Royal Bath) – A ritual where pilgrims in Akharas (processions) bathe in the holy river.
    • Worship and Prayers – Pilgrims offer prayers along riverbanks, attend spiritual discourses, and perform fire rituals.
    • Religious Processions – Several religious processions involving saints, gurus, and devotees take place.
    • Community Prayers and Spiritual Discourses – Saints and religious leaders conduct spiritual teachings for the devotees.
    Significance and Features  
    • Spiritual Significance: Considered a sacred event for Hindus, aimed at spiritual cleansing, salvation, and liberation from the cycle of rebirth (Moksha).
    • Cultural Unity: It is a remarkable event showcasing India’s unity and diversity, where millions of people from across the world come together.
    • Mass Gathering: It holds the Guinness World Record for the largest peaceful gathering, with millions of pilgrims attending the event. In 2019, Kumbh Mela witnessed the largest peaceful public gathering ever recorded, with around 120 million people.
    • Pilgrimage Tourism – The Kumbh Mela also significantly boosts local tourism, with a major influx of national and international pilgrims, contributing to local and national economies.

    UNESCO Recognition – Kumbh Mela was recognized as an Intangible Cultural Heritage of Humanity by UNESCO in 2017.

  • RBI Notifications

    What is Cash Reserve Ratio (CRR)?

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Cash Reserve Ratio (CRR)

    Why in the News?

    • The Reserve Bank of India (RBI) began its three-day monetary policy review.
      • There is increasing speculation that the RBI may announce a cut in the Cash Reserve Ratio (CRR) to ease liquidity pressures.

    What is Cash Reserve Ratio (CRR)?

    • CRR is the percentage of a bank’s total deposits that it must maintain as liquid cash with the Reserve Bank of India (RBI) as a reserve.
    • It is a tool used by the RBI to manage inflation and check excessive lending by banks.
      • It serves as a safety net during times of banking stress, ensuring banks have enough liquidity for day-to-day operations.
    • As of now, the CRR is set at 4.5% of a bank’s Net Demand and Time Liabilities (NDTL).
    • Banks do not earn interest on the amount they maintain as CRR with the RBI.
    • CRR Requirements for Different Types of Banks:
      • Scheduled Commercial Banks (SCBs): Includes Public Sector Banks (PSBs), Private Sector Banks (PVBs), Regional Rural Banks (RRBs), Small Finance Banks (SFBs), Payments Banks, Primary (Urban) Co-operative Banks (UCBs), State Co-operative Banks (StCBs), and District Central Co-operative Banks (DCCBs).
      • Non-Scheduled Co-operative Banks & Local Area Banks: They must maintain CRR with themselves or with the RBI.
    • Restrictions on CRR Funds
      • Banks cannot lend the funds held as CRR to corporates or individual borrowers.
      • The money held under CRR cannot be used for investment purposes by the bank.
      • No Interest is earned on the funds maintained as CRR by banks with the RBI.

    What is Incremental CRR (I-CRR)?

    • Introduced temporarily on August 10, 2023, to absorb surplus liquidity in the banking system.
    • Banks were required to maintain 10% I-CRR on the increase in their NDTL between May 19, 2023, and July 28, 2023.
    • The I-CRR was implemented from August 12, 2023, and applied during periods of excess liquidity in the financial system.

    Impacts of Declining CRR on the Economy

    • Positive Impacts: 
      • Increased Bank Liquidity: A reduction in CRR frees up more funds for banks, improving credit availability and promoting investment and consumption.
      • Stimulus for Economic Growth: With more funds to lend, businesses can secure loans more easily, boosting economic activity and encouraging growth across sectors.
      • Lower Interest Rates: As banks have more liquidity, they may lower interest rates on loans, making credit cheaper and encouraging investment and consumer spending.
    • Negative Impacts: 
      • Potential Inflationary Risks: Increased lending and spending can raise demand, which, if not matched by supply, can lead to inflationary pressures in the economy.
      • Asset Bubbles: Excess liquidity may result in overvalued assets like stocks or real estate, creating the risk of unsustainable price increases and potential market instability.

    PYQ:

    [2010] When the Reserve Bank of India announces an increase of the Cash Reserve Ratio, what does it mean?

    (a) The commercial banks will have less money to lend

    (b) The Reserve Bank of India will have less money to lend

    (c) The Union Government will have less money to lend

    (d) The commercial banks will have more money to lend

  • Wildlife Conservation Efforts

    World Wildlife Conservation Day

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: World Wildlife Conservation Day

    Why in the News?

    • World Wildlife Conservation Day (December 4) reminds us to focus on preserving and protecting the critically endangered species in India and globally.
      • The theme for this year is “Connecting People and Planet: Exploring Digital Innovation in Wildlife Conservation”.

    World Wildlife Conservation Day: Key Facts

    • Observed annually on December 4th.
    • Purpose: Raise awareness about the importance of wildlife conservation and the protection of endangered species and their habitats.
    • It was established in 2012 by the UN, coinciding with the anniversary of the 1948 signing of CITES (Convention on International Trade in Endangered Species).
    • It supports global efforts for wildlife conservation, aligns with SDG 15 (life on land) and SDG 14 (life below water).

    Aims for India’s Critically Endangered Species

    • As of 2022, 73 species in India are classified as critically endangered, meaning they are at highest risk of extinction in the wild.
      • The number of critically endangered species has risen from 47 in 2011, partly due to better data availability and monitoring.
    • India has 9 critically endangered mammal species, out of which 8 are endemic (found only in specific regions within India).
      • These include: Kashmir Stag (Hangul), Malabar Large-spotted Civet, Andaman Shrew, Jenkin’s Shrew, Nicobar Shrew, Namdapha Flying Squirrel, Large Rock Rat, and Leafletted Leaf-nosed Bat.
    • Though these animals receive significant attention for tourism purposes, they are only three of the critically endangered species in India.
      • Lions: Asiatic lions in the Gir Forest are critically endangered.
      • Tigers: Bengal tigers are also listed as critically endangered.
      • Cheetahs: They are also part of India’s endangered wildlife.
    • Great Indian Bustard is a bird facing significant threats due to power lines in Rajasthan.

    PYQ:

    [2014] The most important strategy for the conservation of biodiversity together with traditional human life is the establishment of:

    (a) biosphere reserves

    (b) botanical gardens

    (c) national parks

    (d) wildlife sanctuaries